Diclofenac sodium 4% Spray Gel (DicloFlex®)
First and only,
innovative and
unique Spray form
of Diclofenac
on the market
The Top of anti-inflammatory drug formulation showing:
- Rapid onset and long lasting relief of pain
- Targeted delivery
- High concentration of active substance
- Highest safety profile of topical Diclofenac´s
- Easy to use
Confirmed facts:
- better permeation through the skin than Voltaren Emulgel
- higher drug levels in the target tissue than oral NSAID´s
- low systemic drug exposure = reduced/no systemic side effects
- efficacy in ankle distorsions - reduction of swelling and pain
- outstanding local tolerance – proven in animals and humans
- favourable safety profile – proven in animals and humans
- no phototoxicity or photosensitisation – proven in animals
- no skin irritation or sensitisation – proven in humans
- no effect on gastric prostaglandin synthesis – proven in humans
Optimal pain relief because of:
- carries diclofenac at high concentrations through the skin
- targeted delivery directly directely into the inflammated and painful area
- higher drug-concentration at the desired site (bioavailability of diclofenac in
- subcutaneous adipose and skeletal muscle tissue is higher than after oral dosing)
- rapid onset of action (due to pharmacokinetic properties)
- a reduction of inter-/intra patient variability as compared to oral administration
- a more accurate and constant drug concentration
Rapid absorption:
- fast penetration of the whole formulation into skin
- immediate evaporation of the contained alcohol
Comfortable administration:
- without leaving a remaining fatty surface film (making a surgical dressing unnecessary)
- without gelling substances, known for inhibition of drug penetration
- without additional conserving substances, causing further problems in patients with allergies
- easy-to-handle
- useable under every circumstance
- uniform distribution over the affected site
- amount easy to dose
- pleasant sensation of coolness
- slight peppermint smell
- smoothes the skin
The treatment of choice because of:
- doesn’t let the whole body absorb the NSAID
- inflammation and pain is confined to an injured area of 200 cm2, a single joint or a muscle
- no NSAD’s systemically originated gastric, renal and cardiovascular side effects
- Due to its favourable penetration and low systemic availability, Diclofenac sodium 4% Spray Gel (DicloFlex®) is a safer alternative to oral NSAID’s
- improved benefit/risk ratio
- Tolerability equivalent to placebo
IN CONCLUSION: treatment-protection against gastropathic side-effects is not necessary since the tolerability is equivalent to Placebo